A total of 358 patients with severe aortic stenosis, a heart disease characterized by obstruction of the aortic valve due to calcification, participated in the trial.

总计358名伴严重主动脉瓣狭窄(特征为因钙化主动脉瓣梗阻的一种心脏病)患者参加了这项实验。

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BACKGROUND: -transcatheter aortic valve implantation is an alternative to open heart surgery in patients with aortic stenosis.

背景：除了心内直视手术，经导管主动脉瓣植入术是主动脉狭窄患者的替代治疗方案。

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Jana Pausa, 76, of Atherton, Calif., who had both severe aortic stenosis and lung disease that made her unsuitable for open-heart surgery to replace the diseased heart valve, is one such patient.

Jana Pausa, 76岁，加利福尼亚州阿瑟顿人，有严重主动脉瓣狭窄和使她不适合开心手术置换病损心脏瓣膜的肺部疾病，是一个这样的病例。

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For now, this procedure is usually limited to individuals who have a narrowed aortic valve (aortic stenosis) rather than aortic regurgitation and are considered at high-risk for surgical complications.

CNN: Aortic valve regurgitation

In SEAS, Vytorin failed to do better than placebo at treating a heart valve disease called aortic stenosis, but it did reduce the risk of heart attacks, strokes and operations to unclog arteries.

FORBES: Efficacy Questions Still Dog Vytorin

The blockbuster cholesterol drug Vytorin failed to improve a rare heart valve condition called aortic stenosis and seemed to increase rates of cancer, a new study says, dealing another blow to the top-selling drug and its makers, Merck and Schering-Plough .

FORBES: Another Blow For Merck And Schering